Research Assistant (Opt4TPT Implementation research)

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KNCV Tuberculosis Foundation

KNCV Tuberculosis Foundation (KNCV) is one of the leading international non-profit organizations dedicated to fighting tuberculosis (TB) worldwide. We are an international center of expertise for TB control that stimulates effective, efficient and sustainable tuberculosis control strategies in a national and international context. We are an organization of passionate TB professionals, including medical doctors, researchers, training experts, nurses and epidemiologists.

 Over the past century we have built a wealth of knowledge and expertise, initially by successfully driving back TB in the Netherlands, and subsequently by partnering in the fight against TB in over 40 countries worldwide. We operate from a central office in The Hague in the Netherlands and additional country offices worldwide. KNCV raises funds from individual, institutional and corporate donors. In Ethiopia, KNCV has more than 13 years of experience in comprehensive TB program support of the national program.


  TB preventive therapy (TPT), which involves giving anti-TB drugs to people with dormant TB infections, can reduce the risk of individuals developing active TB disease. But despite being recommended for PLHIV and household contacts of confirmed pulmonary TB patients, delivery and uptake of TPT have been slow and remain suboptimal globally. New innovations, such as a shorter regimen that combines two antibiotics—Isoniazid and Rifapentine—taken once a week for 12 weeks (known as 3HP), provide an opportunity to scale up TPT and are becoming available worldwide. Shorter regimens have potential advantages over the previous standard of care, Isoniazid preventive therapy (IPT), including once weekly dosing, as well as better adherence and completion. However, to effectively scale these new TPT regimens, it is critical that we understand the barriers and facilitators to implementation. Achieving global targets, including those set at the September 2018 UNHLM on TB, not only requires scaling up affordable and safe TPT regimens, but also collecting evidence to guide future implementation and policies.

 The Opt4TPT study is a three-year programmatic assessment of TPT delivery across three countries, namely Ethiopia, South Africa and Zimbabwe, to generate critical knowledge to improve TPT uptake, implementation and outcomes. By following a cohort of PLHIV prospectively and directly observing service delivery in health facilities, Opt4TPT’s approach will provide valuable new knowledge regarding routine use of TPT, as well as outcomes during, and following TPT. This study will create an important understanding of TPT uptake and completion from the patient perspective and delivery from the health system perspective. These results will provide actionable information for improving service delivery and the scale-up of TPT. The project also assess the cost of patients of taking TPT, seeking care for symptom of TB, as well as any TB related illness.

  Purpose of the position and organizational position

As part of the implementation of Opt4TPT project in Ethiopia, we will conduct qualitative, quantitative, and health economic research to:

  • Quantify the TPT continuum of care—from treatment initiation to completion—among PLHIV eligible for TPT and describe reasons for TPT refusal, discontinuation and completion, including patient perceptions, adverse events, drug tolerability, incident TB and death.
  • Identify key system and provider characteristics, including models of care present in a clinic contributing to TPT prescribing, including clinic structures, clinician attitudes, and knowledge of and adherence to local TPT prescribing guideline.
  • Conduct cost-effectiveness analysis to compare different TPT delivery strategies.

 As a Research Assistant, you are expected to actively engage in participant recruitment and enrolment, in research-related activities, actively participant retention, and support general administration activities.

  Place in the organization

The research assistant reports to the Project Coordinator. The Research Assistant works closely the Research Nurse, staff at study sites, the value stream mapping consultants and IMPAACT4TB team.

3 positions

What does KNCV Tuberculosis Foundation offer?

  •  A full time (40 hours) fixed-term contract for one year, with the intention to extend the contract;
  • An informal work atmosphere in an international environment, where initiative is appreciated;
  • A highly motivated team of experienced, self-driven colleagues;
  • The salary is dependent upon education and relevant working experience.

Job Requirements


 As Research Assistant your activities will be to:

  • Recruit potential participants for the study;
  • Ensure that potential participants are provided with all the study details as described in the Participant Information Sheet;
  • Administer written informed consent;
  • Recruit and schedule appointments for qualitative study participants;
  • Assist the research nurse to plan recruitment schedules;
  • Conduct enrolment activities;
  • Being responsible for the proper documentation of all study activities;
  • Administer data collection instruments as required;
  • Perform quality checks on collected data and perform data query resolution;
  • Complete, compile, and submit study case report forms (CRFs) and source documents timely;
  • Ensure all records on participants are completed and accurately filed with strict adherence to documentation handling procedures;
  • Maintain accurate study logs related to enrolment and other study activities;
  • Report on daily/weekly activities to the research nurse and project Coordinator and meet stipulated enrolment and follow-up targets;
  • Retain participants by obtaining, verifying and updating detailed locator data from participant for all visits;
  • Reminding participants about their appointments just prior to each visit;
  • Following-up on participants to ensure study completion;
  • Prepare participant files and documents;
  • Reconcile reimbursement of participants;
  • Make sure safe storage and transportation of complete study documents is done properly,

Qualifications and experience

  • Diploma in nursing or related field;
  • Experience in research at least 3 years;
  • Knowledge of HIV/TB diagnosis, treatment and care issues;
  • Experience in collecting qualitative and quantitative data and ensuring quality of data collected;
  • Experienced in data entry and transcription;
  • Experience working with staff in public healthcare facilities is advantageous;
  • Knowledge of Microsoft Office, Research methods, GCP training;
  • Good communication skills;
  • Ability to solve practical problems;
  • Good management and interpersonal skills;
  • Proficient in written and spoken English and fluency in local languages;
  • Ability to work independently and in a team;
  • Ability to work under pressure;
  • Good numerical skills;
  • Able to pay close attention to detail.

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